A POWERFUL RESEARCH AND
                      DEVELOPMENT ENGINE

                      Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

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                      Regeneron Pipeline: Phase 1 Medicines Regeneron Pipeline: Phase 1 Medicines
                      • CEMIPLIMAB*
                        PD-1 Antibody Cancer
                      • REGN3767
                        LAG-3 Antibody Solid tumors, advanced hematologic malignancies
                      • REGN1979
                        CD20 X CD3 Antibody B-cell malignancies
                      • REGN4018*
                        MUC16 X CD3 Antibody Platinum-resistant ovarian cancer
                      • REGN5458*
                        BCMA X CD3 Antibody Multiple myeloma
                      • REGN5459*
                        BCMA X CD3 Antibody Multiple myeloma
                      • REGN5678
                        PSMA X CD28 Antibody Prostate cancer
                      • REGN5093
                        MET X MET Antibody MET-altered advanced non-small cell lung cancer (NSCLC)
                      • REGN5713-5714-5715
                        Bet v 1 Antibodies Birch Allergy
                      Regeneron Pipeline: Phase 2 Medicines Regeneron Pipeline: Phase 2 Medicines
                      • AFLIBERCEPT
                        VEGF-Trap High-dose (8mg) for wet age-related macular degeneration (AMD)
                      • CEMIPLIMAB*
                        PD-1 Antibody Basal cell carcinoma (BCC), metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), neoadjuvant CSCC
                      • REGN1979
                        CD20 X CD3 Antibody B-cell non-Hodgkin lymphoma
                      • SARILUMAB*
                        IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis
                      • DUPILUMAB*
                        IL-4R Antibody Grass allergy, peanut allergy
                      • REGN1908-1909
                        Fel d 1 Antibodies Cat allergy
                      • REGN3500*
                        IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD)
                      • REGN5069
                        GFRα3 Antibody Osteoarthritis pain of the knee
                      • GARETOSMAB
                        Activin A Antibody Fibrodysplasia Ossificans Progressiva (FOP)
                      • EVINACUMAB
                        ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia
                      • POZELIMAB
                        C5 Antibody Paroxysmal nocturnal hemoglobinuria, CD-55 deficient protein-losing enteropathy
                      • REGN4461
                        LEPR Antibody Generalized lipodystrophy
                      Regeneron Pipeline: Phase 3 Medicines Regeneron Pipeline: Phase 3 Medicines
                      • AFLIBERCEPT
                        VEGF-Trap Retinopathy of prematurity (ROP)
                      • CEMIPLIMAB*
                        PD-1 Antibody non-small cell lung cancer (NSCLC), cervical cancer, adjuvant cutaneous squamous cell carcinoma (CSCC)
                      • ALIROCUMAB
                        PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatric patients, heterozygous familial hypercholesterolemia in pediatric patients
                      • EVINACUMAB
                        ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH)
                      • DUPILUMAB*
                        IL-4R Antibody Atopic dermatitis in pediatric patients 6 mo.–11 y.o., asthma in pediatric patients 6-11 y.o., eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, prurigo nodularis, chronic spontaneous urticaria
                      • SARILUMAB*
                        IL-6R Antibody Hospitalized "critical" COVID-19 patients, polymyalgia rheumatica, giant cell arteritis
                      • REGN-EB3
                        Ebola Virus Antibodies Ebola virus infection
                      • FASINUMAB?
                        NGF Antibody Osteoarthritis pain of the knee or hip

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                      * In collaboration with Sanofi

                      ? In collaboration with Teva and Mitsubishi Tanabe

                      This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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